We developed a comprehensive three-dimensional ultrasound breast imaging to differentiate benign and malignant lesions based on local, quantitative, ultrasound, tissue properties. We used an innovative design to acquire three-dimensional projections and then used sophisticated three-dimensional reconstruction algorithms to generate ultrasound tissue property images. The use of quantitative images permitted the development of accurate computer-assisted diagnosis algorithms. We manufactured a device using omni-directional piezoelectric crystals that act both as transmitters and receivers of ultrasound. Each crystal “talks” to all of the other crystals, allowing us to measure ultrasound tissue properties from a multitude of directions concurrently. We call this technique sono computed tomography (SCT). It is a unique subtype of a technique that was first explored in the 1970’s called ultrasound computed tomography. We developed an easy, intuitive visualization tool for the radiologist to use to read the scans.